PREDICTORS OF IRON OVERLOAD TOXICITY IN MULTI-TRANSFUSED BETA-THALASSEMIC CHILDREN
نویسندگان
چکیده
منابع مشابه
Assessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients
Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, the...
متن کاملEvaluation of puberty in relation to iron overload in multi transfused B-thalassemia patients
Objective; Prospective study to determine the prevalence of delayed puberty in thalassemia major patients in Sohag University Hospital. This study also aimed to determine serum gonadotropin and sex hormone levels in these patients and correlate these to their serum ferritin. Methods; This cross sectional study included 30 Thalassemia Major Patients, aged 12 to 18 years. Puberty was assessed cli...
متن کاملIron overload in multiply transfused patients who are HIV seropositive.
AIMS To assess histologically the amount of iron deposited in liver biopsy specimens from HIV positive patients; and to perform estimations of liver iron on tissue from patients with an increase in parenchymal stainable iron. To correlate the amount of blood transfused and the degree of iron overload. METHODS Liver biopsy specimens (n = 120) from 109 HIV positive patients, 74 of whom had AIDS...
متن کاملIncreased oxidative stress and iron overload in Jordanian β-thalassemic children.
β-Thalassemia (β-thal) is associated with abnormal synthesis of hemoglobin (Hb). Repeated blood transfusions in patients with β-thal major (β-TM) leads to an enhanced generation of reactive oxygen species (ROS), and subjects patients to peroxidative injury. We studied the antioxidant status and oxidative damage to children with β-thal in Jordan. Samples from 40 children with β-thal and 40 healt...
متن کاملIRON OVERLOAD IN BETA THALASSEMIA – A Review
Due to improvements in transfusion therapy in beta-thalassemia major patients, transfusional hemosiderosis has now become the major cause of late morbidity and mortality in them. In India and other developing countries, iron chelation therapy is still not strictly adhered to in these children, mostly due to financial constraints. An orally effective and cheap iron chelator is the need of the ho...
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ژورنال
عنوان ژورنال: Volume 6, Issue 7
سال: 2019
ISSN: 2349-6126,2349-6118
DOI: 10.32677/ijch.2019.v06.i07.003